Acute intake of fructooligosaccharide and partially hydrolyzed guar gum on gastrointestinal transit: A randomized crossover clinical trial.

Marcelo Victor Teixeira da Silva, Shirleide Santos Nunes, Walyson Coelho Costa, Sandra Monetti Dumont Sanches, Ana Letícia Malheiros Silveira, Álida Rosária Silva Ferreira, Roberta Silva Filha, Maria Isabel T D Correia, Luciene das Graças Mota, Simone de Vasconcelos Generoso

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 2022;102():111737

PMID: 35843106

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVES

Dietary fibers, such as fructooligosaccharide (FOS) and partially hydrolyzed guar gum (PHGG) have several gastrointestinal functions. The aims of this study were to evaluate the effect of acute ingestion of FOS and PHGG on the percentage of gastric emptying and small intestinal transit and to evaluate the effect of these dietary fibers on the levels of intestinal hormones-active glucagon-like peptide-1, pancreatic polypeptide, and gastric inhibitory peptide-and their effect on feelings of hunger and satiety and the desire to eat.

METHODS

In this crossover, randomized controlled clinical trial, we compared the effects of these two fibers on gastrointestinal transit. The tests were performed using scintigraphy. On three different days, healthy participants consumed a test meal containing 20 g of digestible maltodextrin (placebo), 20 g of FOS, or 20 g of PHGG.

RESULTS

The gastric emptying of the FOS-based diet (84.2 ± 9.4%) within 2 h was statistically increased compared with the placebo and PHGG-based diets (78 ± 10.2% and 74 ± 15.3%, respectively; P < 0.05). However, a reduction in small intestinal transit was observed after consumption of both FOS- and PHGG-based diets (28.5 ± 15.56% and 24.2 ± 13.7%, respectively) compared with the placebo diet (41.20 ± 15.4%; P < 0.05). There were no changes in the levels of intestinal hormones, feeling of hunger and satiety, or desire to eat after consuming the three diets (P > 0.05).

CONCLUSION

The acute intake of FOS increased gastric emptying, whereas both FOS and PHGG reduced small intestine transit without altering the levels of intestinal hormones, hunger feelings and satiety, or the desire to eat.

Address: Department of Food, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Department of Anatomy and Image, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Department of Nutrition, Nursing School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Demography Post-graduation Program, Economic Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Department of Physiology and Biophysics, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Department of Surgery, Medical School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Department of Nutrition, Nursing School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: [email protected].

DOI: 10.1016/j.nut.2022.111737

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MeSH Terms: Dietary Fiber, Galactans, Gastrointestinal Hormones, Gastrointestinal Transit, Humans, Mannans, Oligosaccharides, Plant Gums