The gut microbiome as a modulator of healthy ageing.

Tarini Shankar Ghosh, Fergus Shanahan, Paul W O'Toole

Journal: Nature reviews. Gastroenterology & hepatology 2022;19(9):565-584

PMID: 35468952

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Abstract

The gut microbiome is a contributory factor in ageing-related health loss and in several non-communicable diseases in all age groups. Some age-linked and disease-linked compositional and functional changes overlap, while others are distinct. In this Review, we explore targeted studies of the gut microbiome of older individuals and general cohort studies across geographically distinct populations. We also address the promise of the targeted restoration of microorganisms associated with healthier ageing.

Address: APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland.; School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland.; Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland.; APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland. [email protected].; School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland. [email protected].

DOI: 10.1038/s41575-022-00605-x

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MeSH Terms: Gastrointestinal Microbiome, Healthy Aging, Humans