Effects of microRNAs and long non-coding RNAs on chemotherapy response in glioma.

Sara Ahmadpour, Tarannomsadat Taghavi, Amirhossein Sheida, Seyed Saeed Tamehri Zadeh, Michael R Hamblin, Hamed Mirzaei

Journal: Epigenomics 2022;14(9):549-563

PMID: 35473299

Abstract

Glioma is the most prevalent invasive primary tumor of the central nervous system. Glioma cells can spread and infiltrate into normal surrounding brain tissues. Despite the standard use of chemotherapy and radiotherapy after surgery in glioma patients, treatment resistance is still a problem, as the underlying mechanisms are still not fully understood. Non-coding RNAs are widely involved in tumor progression and treatment resistance mechanisms. In the present review, we discuss the pathways by which microRNAs and long non-coding RNAs can affect resistance to chemotherapy and radiotherapy, as well as offer potential therapeutic options for future glioma treatment.

Address: Department of Biotechnology, Faculty of Chemistry, University of Kashan, Kashan, Iran.; Department of Cell & Moleclar Biology, University of Tehran, Tehran, Iran.; School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa.; Research Center for Biochemistry & Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.

DOI: 10.2217/epi-2021-0439

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MeSH Terms: Gene Expression Regulation, Neoplastic, Glioma, Humans, MicroRNAs, RNA, Long Noncoding