Regulation and role of CAMKK2 in prostate cancer.

Thomas L Pulliam, Pavithr Goli, Dominik Awad, Chenchu Lin, Sandi R Wilkenfeld, Daniel E Frigo

Journal: Nature reviews. Urology 2022;19(6):367-380

PMID: 35474107

Full Text on Nature Publishing Group View on PubMed

Abstract

In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a driver of prostate cancer progression. Results from multiple independent studies have confirmed these findings and demonstrated the potential role of CAMKK2 as a clinical biomarker and therapeutic target in advanced prostate cancer using a variety of preclinical models. Drug development efforts targeting CAMKK2 have begun accordingly. CAMKK2 regulation can vary across disease stages, which might have important implications in the use of CAMKK2 as a biomarker. Moreover, new non-cell-autonomous roles for CAMKK2 that could affect tumorigenesis, metastasis and possible comorbidities linked to disease and treatment have emerged and could present novel treatment opportunities for prostate cancer.

Address: Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for Nuclear Receptors and Cell Signalling, University of Houston, Houston, TX, USA.; Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.; Rice University, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [email protected].; Center for Nuclear Receptors and Cell Signalling, University of Houston, Houston, TX, USA. [email protected].; Department of Biology and Biochemistry, University of Houston, Houston, TX, USA. [email protected].; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [email protected].; The Houston Methodist Research Institute, Houston, TX, USA. [email protected].

DOI: 10.1038/s41585-022-00588-z

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https://doi.org/10.1038/s41585-022-00588-z

MeSH Terms: Calcium-Calmodulin-Dependent Protein Kinase Kinase, Cell Line, Tumor, Cell Transformation, Neoplastic, Humans, Male, Prostate, Prostatic Neoplasms