Injectable multifunctional hyaluronic acid/methylcellulose hydrogels for chronic wounds repairing.

Linyu Long, Cheng Hu, Wenqi Liu, Can Wu, Lu Lu, Li Yang, Yunbing Wang

Journal: Carbohydrate polymers 2022;289():119456

PMID: 35483858

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Abstract

Herein, an injectable multifunctional hydrogel based on dopamine grafted hyaluronic acid and phenylboric acid grafted methylcellulose was fabricated for promoting the repair of diabetic wounds. The prepared hydrogel possessed multifunctional properties including rapid gelation time (less than 10 s), self-healing, high water absorbency, tissue adhesiveness and excellent antioxidant activity. After loading Ag nanoparticles and the recombinant humanized collagen type III with high affinity to cells, the hydrogel exhibited properties of pH-/HO-responsive drug release profile, promoting cell proliferation and ideal antibacterial activity. Moreover, the in vivo experimental results demonstrated the prepared hydrogel could significantly accelerate wound repair by enhancing the collagen deposition and granulation tissue regeneration, reducing the expression of CD68 and improving the production of Ki67 and CD31 simultaneously. In conclusion, these multifunctional injectable hydrogels possessed great potential in chronic wound dressings.

Address: National Engineering Research Center for Biomaterials, Chuanda-Jinbo Joint Research Center, Sichuan University, Chengdu, 610064, China.; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan-Jinbo Joint Research Center, Fudan University, Shanghai 200302, China.; National Engineering Research Center for Biomaterials, Chuanda-Jinbo Joint Research Center, Sichuan University, Chengdu, 610064, China. Electronic address: [email protected].; National Engineering Research Center for Biomaterials, Chuanda-Jinbo Joint Research Center, Sichuan University, Chengdu, 610064, China. Electronic address: [email protected].

DOI: 10.1016/j.carbpol.2022.119456

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MeSH Terms: Hyaluronic Acid, Hydrogels, Hydrogen Peroxide, Metal Nanoparticles, Methylcellulose, Silver