Research progress on the relationship between IS and kidney disease and its complications.

Yan Gao, Ye Li, Xueting Duan, Qian Wang, Haisong Zhang

Journal: International urology and nephrology 2022;54(11):2881-2890

PMID: 35488145

Abstract

Indoxyl sulphate (IS) a representative uraemic toxin in the blood of patients with chronic kidney disease (CKD). Its accumulation may be closely related to CKD and the increasing morbidity and mortality of the disease's related complications. Timely and effective detection of the IS level and efficient clearance of IS may effectively prevent the progression of CKD and its related complications. Therefore, this article summarizes the research progress of IS related, including IS in CKD and its associated complications including chronic kidney disease, chronic kidney disease with cardiovascular disease, renal anemia, bone mineral metabolic disease and neuropsychiatric disorders, looking for IS accurate rapid detection methods, and explore the efficient treatment to reduce blood levels of indole phenol sulphate.

Address: Department of Nephrology, Affiliated Hospital of Hebei University, No. 212 Yuhuadonglu, Baoding, 071000, People's Republic of China.; College of Clinical Medicine, Hebei University, No. 342 Yuhua Road, Baoding, 071000, People's Republic of China.; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, No. 212 Yuhuadonglu, Baoding, 071000, People's Republic of China.; Department of Nephrology, Affiliated Hospital of Hebei University, No. 212 Yuhuadonglu, Baoding, 071000, People's Republic of China. [email protected].; College of Clinical Medicine, Hebei University, No. 342 Yuhua Road, Baoding, 071000, People's Republic of China. [email protected].; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, No. 212 Yuhuadonglu, Baoding, 071000, People's Republic of China. [email protected].; Department of Nephrology, Affiliated Hospital of Hebei University, No. 212 Yuhuadonglu, Baoding, 071000, People's Republic of China. [email protected].; College of Clinical Medicine, Hebei University, No. 342 Yuhua Road, Baoding, 071000, People's Republic of China. [email protected].; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, No. 212 Yuhuadonglu, Baoding, 071000, People's Republic of China. [email protected].

DOI: 10.1007/s11255-022-03209-1

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https://doi.org/10.1007/s11255-022-03209-1

MeSH Terms: Humans, Indican, Phenols, Renal Insufficiency, Chronic, Sulfates, Uremic Toxins