Electroporation, electrochemotherapy and electro-assisted drug delivery in cancer. A state-of-the-art review.

Iana Tsoneva, Severina Semkova, Rumiana Bakalova, Zhivko Zhelev, Philippe Nuss, Galya Staneva, Biliana Nikolova

Journal: Biophysical chemistry 2022;286():106819

PMID: 35605496

Full Text on Elsevier Science View on PubMed

Abstract

This review focuses on electrochemotherapy that consists in the delivery of anti-cancer drugs using high-voltage electrical pulses. Technical issues, choice of drugs, and protocol of drug delivery are still under investigation and no consensus has been achieved yet. The different aspects of electrochemotherapy are discussed in the present paper. It includes interrogations about the choice of the preferred anti-cancer drug and dose to be delivered on the solid tumors. Another promising area is related to the electro-assisted release of nanoparticles (quantum dots) in xenografted solid tumors. Molecular mechanisms of enhanced drug delivery are discussed in terms of high cholesterol level and large fraction of lipid rafts in cancer cells. Electrochemotherapy is a paradigmatic example of cooperation between physicists, biophysicists, chemists, technicians, manufacturers, biologists, clinicians, and patients to improve a very promising treatment delivery in line with the conception of personalized medicine.

Address: Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, Sofia 1113, Bulgaria.; Department of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku Chiba 263-8555, Japan; Medical Faculty, Sofia University "St. Kliment Ohridski", Sofia, Bulgaria.; Service de Psychiatrie et de Psychologie Medicale, Sorbonne Universite, Hopital Saint-Antoine, AP-HP, Paris, France; Centre de Recherche Saint-Antoine, INSERM UMRS 938, Sorbonne Universite, Paris, France.; Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, Sofia 1113, Bulgaria. Electronic address: [email protected].; Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, Sofia 1113, Bulgaria. Electronic address: [email protected].

DOI: 10.1016/j.bpc.2022.106819

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MeSH Terms: Antineoplastic Agents, Drug Delivery Systems, Electrochemotherapy, Electroporation, Humans, Neoplasms, Pharmaceutical Preparations