The effect of conjugated linoleic acid supplementation on oxidative stress markers: A systematic review and meta-analysis of randomized controlled trials.

Wanich Suksatan, Husna Dharma Putera, Adnan Hashim Abdulkadhim, Ali Thaeer Hammid, Jamshid A Ismailov, Behrooz Jannat, Rezayat Parvizi, Fatemeh Izadi

Journal: Clinical nutrition ESPEN 2022;49():121-128

PMID: 35623803

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND & AIMS

Recent trial studies have found that conjugated linoleic acid (CLA) supplementation beneficially reduces oxidative stress markers but, there is no definitive consensus on this context. The present systematic review and meta-analysis aimed to investigate the effect of CLA supplementation on oxidative stress parameters.

METHODS

We searched PubMed, Web of Science, Scopus, Cochrane Library, and Google Scholar databases until September 2021 to identify randomized controlled trials (RCTs) assessing CLA supplementation effects on oxidative markers including malondialdehyde (MDA), 8-isoprostanesF2α (8-iso-PGF2α), and glutathione peroxidase (GPx). Summary estimates and corresponding 95% confidence intervals (CI) were derived via the DerSimonian and Laird method using a random-effects model.

RESULTS

A total of 11 RCTs were included. The obtained results show that CLA supplementation caused a significant decrease in MDA concentrations (Hedges's: -0.35; 95% CI: -0.70 to -0.01, P = 0.04, I = 62.1%, n = 7), and also significantly increased 8-iso-PGF2α levels (Hedges's: 1.45; 95% CI: 0.98 to 1.91, P˂0.001, I = 42.9%, n = 4). However, the results showed that supplementation with CLA did not significantly change the concentrations of GPx (Hedges's: 0.30; 95% CI: -0.04 to 0.64, P = 0.08, I = 0.0%, n = 3).

CONCLUSION

It seems this supplement can be used as a dietary supplement to improve oxidative stress parameters. However, further studies are required to demonstrate present results.

Address: Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.; Department of Surgery, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia.; Department of Computer Engineering, Technical Engineering College, Al-Ayen University, Thi-Qar, Iraq.; Computer Engineering Techniques Department, Faculty of Information Technology, Imam Ja'afar Al-Sadiq University, Baghdad, Iraq.; Department of DKTF Internal Medicine, Samarkand State Medical Institute, Amir Temur Street 18, Samarkand, Uzbekistan; Department of Scientific Affairs, Tashkent State Dental Institute, Makhtumkuli Street 103, Tashkent, 100047, Uzbekistan.; Halal Research Center of IRI, FDA, Tehran, Iran.; Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: [email protected].; Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: [email protected].

DOI: 10.1016/j.clnesp.2022.04.004

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MeSH Terms: Biomarkers, Dietary Supplements, Humans, Linoleic Acids, Conjugated, Oxidative Stress, Randomized Controlled Trials as Topic