Topical immunopharmacology of ocular allergies.

Leonard Bielory, Duraisamy Kempuraj, Theoharis Theoharides

Journal: Current opinion in allergy and clinical immunology 2003;2(5):435-45

PMID: 12582329

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

PURPOSE OF REVIEW

To review the histamine-1 receptor antagonists, mast cell blockers and natural agents with such actions that can be used for the topical treatment of ocular allergies.

RECENT FINDINGS

Increasing evidence indicates that some histamine-1 receptor antagonists have additional actions to inhibit secretion of inflammatory mediators, especially cytokines, from ocular mast cells and other cell types. Emerging information suggests that such actions may be through regulation of intracellular calcium ion levels of NF-kappaB activation.

SUMMARY

A number of available drugs and natural non-prescription agents may have anti-histaminic and anti-inflammatory actions.

Address: Department of Medicine, UMDNJ, Asthma and Allergy Research Center, New Jersey Medical School, Newark, New Jersey, USA. [email protected]

DOI: 10.1097/00130832-200210000-00012

Link outs

Free resources

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-BRIP1-5

Subscription / membership required

Full Text Sources:

MeSH Terms: Administration, Topical, Anti-Inflammatory Agents, Conjunctivitis, Allergic, Evidence-Based Medicine, Histamine Agonists, Humans, Immunotherapy, Mast Cells, Ophthalmic Solutions