Recent Advances in Structural Studies of Cytochrome and Its Potential Application as a Drug Target.

["Cytochrome is a triheme copper-free terminal oxidase in membrane respiratory chains of prokaryotes. This unique molecular machine couples electron transfer from quinol to O with the generation of a proton motive force without proton pumping. Apart from energy conservation, the enzyme plays an additional key role in the microbial cell, being involved in the response to different environmental stressors. Cytochrome promotes virulence in a number of pathogenic species that makes it a suitable molecular drug target candidate. This review focuses on recent advances in understanding the structure of cytochrome and the development of its selective inhibitors."]