FTO in cancer: functions, molecular mechanisms, and therapeutic implications.

Yangchan Li, Rui Su, Xiaolan Deng, Yong Chen, Jianjun Chen

Journal: Trends in cancer 2022;8(7):598-614

PMID: 35346615

Full Text on Elsevier Science View on PubMed

Abstract

N-methyladenosine (mA) is the most abundant internal modification in mRNA that affects RNA processing, stability, and translation. Discovered as the first RNA mA demethylase, the fat mass and obesity-associated protein (FTO) is frequently dysregulated and plays important roles in various types of cancers. Targeting FTO holds promising therapeutic significance via suppressing tumor growth, potentiating immunotherapy, and attenuating drug resistance. Here, we review recent advances in our understanding of the functions and underlying molecular mechanisms of FTO in tumor development, cancer stem cell (CSC) self-renewal, microenvironment regulation, immunity, and metabolism and discuss the therapeutic potential of targeting FTO for cancer treatment.

Address: Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA. Electronic address: [email protected].; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.; Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA. Electronic address: [email protected].

DOI: 10.1016/j.trecan.2022.02.010

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MeSH Terms: Adenosine, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Humans, Neoplasms, RNA, RNA, Messenger, Tumor Microenvironment