Lipids and lipoproteins in cardiovascular diseases: a classification.

Shruti Bhargava, Sofia de la Puente-Secades, Leon Schurgers, Joachim Jankowski

Journal: Trends in endocrinology and metabolism: TEM 2022;33(6):409-423

PMID: 35370062

Free Full Text on Elsevier Science View on PubMed

Abstract

Lipids and lipoproteins, their metabolism, and their transport are essential contributing factors of cardiovascular disease (CVD) as they regulate plasma cholesterol concentration, enhancing cholesterol uptake by macrophages, leading to foam cell formation and ultimately resulting in plaque formation and inflammation. However, lipids and lipoproteins have cardioprotective functions as well, such as preventing oxidation of proatherogenic molecules and downregulating inflammatory proteins.

Address: Institute of Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands.; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands.; Institute of Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands. Electronic address: [email protected].

DOI: 10.1016/j.tem.2022.02.001

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MeSH Terms: Cardiovascular Diseases, Cholesterol, Foam Cells, Humans, Lipoproteins, Macrophages