Skin Testing Approaches for Immediate and Delayed Hypersensitivity Reactions.

Annick Barbaud, Antonino Romano

Journal: Immunology and allergy clinics of North America 2022;42(2):307-322

PMID: 35469620

Full Text on Elsevier Science View on PubMed

Abstract

In evaluating adverse drug reactions (ADRs), patch tests (PTs), skin prick tests (SPTs), and intradermal tests (IDTs) are useful tools for identifying responsible drugs and finding safe alternatives. Their diagnostic value depends on the clinical features of the ADR and on the drug tested. PTs have a good sensitivity in assessing acute generalized exanthematous pustulosis and drug rash with eosinophilia and systemic symptoms. SPTs done with all drugs except opiates are used for immediate hypersensitivity reactions. IDTs seem sensitive for immediate hypersensitivity reactions to beta-lactam antibiotics, iodinated contrast media, heparins, general anesthetics, and platinum salts.

Address: département de Dermatologie et Allergologie, Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP.Sorbonne Université, Hôpital Tenon, Paris F75020, France. Electronic address: [email protected].; Oasi Research Institute-IRCCS, Troina, Italy.

DOI: 10.1016/j.iac.2022.01.003

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MeSH Terms: Drug Hypersensitivity, Drug-Related Side Effects and Adverse Reactions, Humans, Hypersensitivity, Delayed, Hypersensitivity, Immediate, Patch Tests, Skin Tests