Monoterpenoid indole alkaloids with potential neuroprotective activities from the stems and leaves of .

Yu-Jie Li, Juan Li, Lan Xie, Jun-Yu Zhou, Qiu-Xuan Li, Rui-Yuan Yang, Yan-Ping Liu, Yan-Hui Fu

Journal: Natural product research 2022;36(20):5181-5188

PMID: 33960216

Abstract

A chemical study on the stems and leaves of resulted in the isolation and identification of a new monoterpenoid indole alkaloid, melodicochine A (), together with seven known monoterpenoid indole alkaloids (-). The chemical structure of was elucidated on the basis of extensive spectral data analyses and the known compounds were identified by comparing their experimental spectral data with the reported data in the literature. All isolated indole alkaloids were evaluated for their neuroprotective effects against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells . Monoterpenoid indole alkaloids - exhibited notable neuroprotective effects with EC values in range of 0.72 ± 0.06 to 17.89 ± 0.16 M.[Formula: see text].

Address: Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China.; Engineering Research Center for Industrialization of Southern Medicinal Plants Resources of Hainan Province, Hainan Normal University, Haikou, P. R. China.; Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China.; Key Laboratory of Research and Development of Tropical Fruit and Vegetable of Haikou City, Hainan Normal University, Haikou, P. R. China.; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P. R. China.

DOI: 10.1080/14786419.2021.1922406

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MeSH Terms: Antineoplastic Agents, Phytogenic, Apocynaceae, Humans, Indole Alkaloids, Molecular Structure, Monoterpenes, Neuroblastoma, Neuroprotective Agents, Oxidopamine, Plant Leaves, Secologanin Tryptamine Alkaloids