Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox.

Maria Laura Ontario, Rosalba Siracusa, Sergio Modafferi, Maria Scuto, Sebastiano Sciuto, Valentina Greco, Maria Paola Bertuccio, Angela Trovato Salinaro, Roberto Crea, Edward J Calabrese, Rosanna Di Paola, Vittorio Calabrese

Journal: Mechanisms of ageing and development 2022;203():111637

PMID: 35122769

Full Text on Elsevier Science View on PubMed

Abstract

Most chronic illnesses are caused by the biological reaction to an injury, rather than the initial injury or the injurious agent itselves as in neurodegeneration. With respect to this, notable attention is emerging on the therapeutic effects of dietary polyphenols for human health, able to counteract and neutralize oxidative stress and inflammatory processes involved in the etiopathogenesis of major neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. The acquired concept that cellular stress at low doses induces neuroprotective responses against degenerative processes is a frontier area of the neurobiological research focusing on the development of novel preventive and therapeutic interventions for neurodegenerative disorders. Notably, basal levels of prooxidant species are essential to promote adaptive redox cellular responses including vitagenes, tightly correlated to cell survival against age-related diseases. In this paper we discuss the concept of cellular stress response and hormesis and its applications to the field of neuroprotection and the potential therapeutic support provided by olive polyphenols, in particular hydroxytyrosol (HT)-rich aqueous olive pulp extract (Hidrox), as a pivotal activator of Nrf2 pathway and related vitagenes, and inhibitor of Keap1-Nrf2 interaction.Olive polyphenols are considered potential pharmacological modulators of neuroinflammation by upregulation of the Keap1/Nfr2/ARE pathway thus providing a strong rationale for treating neurodegenerative disorders.

Address: Department of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia n.97, Catania 95125, Italy. Electronic address: [email protected].; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy. Electronic address: [email protected].; Department of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia n.97, Catania 95125, Italy.; Department of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia n.97, Catania 95125, Italy. Electronic address: [email protected].; Department of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia n.97, Catania 95125, Italy. Electronic address: [email protected].; Department of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia n.97, Catania 95125, Italy. Electronic address: [email protected].; Department of Biomedical and Dental Sciences and Morpho-functional Imaging, University of Messina, via C. Valeria, 98125 Messina, Italy. Electronic address: [email protected].; Department of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia n.97, Catania 95125, Italy. Electronic address: [email protected].; Oliphenol LLC., 26225 Eden Landing Road, Unit C, Hayward, CA 94545 USA. Electronic address: [email protected].; Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy. Electronic address: [email protected].; Department of Biomedical and Biotechnological Sciences, University of Catania, via S. Sofia n.97, Catania 95125, Italy. Electronic address: [email protected].

DOI: 10.1016/j.mad.2022.111637

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MeSH Terms: Biological Products, Humans, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, Neurodegenerative Diseases, Olea, Oxidative Stress, Polyphenols