Unconventional roles of lactate along the tumor and immune landscape.

Luigi Ippolito, Pierre Sonveaux, Paola Chiarugi

Journal: Trends in endocrinology and metabolism: TEM 2022;33(4):231-235

PMID: 35168874

Full Text on Elsevier Science View on PubMed

Abstract

The tumor ecosystem evolves with dynamic interactions between cancer and normal cells, and nutrients have emerged as new regulators of cancer hallmarks. Lactate has climbed the rankings as a multifunctional molecule orchestrating many aspects of the disease onset and progression. Here, we patchwork and discuss the main recent findings conferred during the EMBO workshop titled 'Lactate: Unconventional Roles of a Nutrient Along the Tumor Landscape.'

Address: Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.; Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain (UCLouvain), Brussels, Belgium.; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; Tuscany Tumor Institute (ITT) and Excellence Centre for Research, Transfer and High Education DenoTHE, Florence, Italy. Electronic address: [email protected].

DOI: 10.1016/j.tem.2022.01.005

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MeSH Terms: Ecosystem, Humans, Lactic Acid, Neoplasms