Multiple roles of apelin/APJ system in eye diseases.

Jingshun Luo, Qun Zhao, Zhiyue Li, Linxi Chen

Journal: Peptides 2022;152():170767

PMID: 35181348

Full Text on Elsevier Science View on PubMed

Abstract

Apelin is an endogenous ligand of G protein-coupled receptor (APJ), and they compose apelin/APJ system. Apelin/APJ system is widely distributed in tissues and plays pleiotropic roles. Attractively, more emphasis has recently been placed on the effects of apelin/APJ system in eye diseases, such as retinopathy of prematurity (ROP), diabetic retinopathy (DR) and diabetic macular edema (DME). In this review, we elaborated the roles of apelin/APJ system in the pathophysiological processes of eye. Concretely, apelin/APJ system induces retinal gliosis and angiogenesis. Hypoxia-inducible factors (HIFs) are involved in apelin/APJ system-triggered ROP progress. Apelin/APJ system mediates DR-induced retinopathy. Apelin/APJ system maintains retinal functions and health by protecting Müller cells from apoptosis. Apelin/APJ system suppresses the NMDA-induced retinal ganglion cell (RGC) loss to protect optic nerve damage. Overall, apelin/APJ system is a potential therapeutic target for eye disease.

Address: Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.; Health Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: [email protected].; Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China. Electronic address: [email protected].

DOI: 10.1016/j.peptides.2022.170767

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MeSH Terms: Apelin, Apelin Receptors, Diabetic Retinopathy, Humans, Infant, Newborn, Macular Edema, Receptors, G-Protein-Coupled