Mechanisms of antidiabetic drugs and cholesterol efflux: A clinical perspective.

Ali Ahmadi, Mariam Bagheri Ekta, Amirhossein Sahebkar

Journal: Drug discovery today 2022;27(6):1679-1688

PMID: 35182734

Full Text on Elsevier Science View on PubMed

Abstract

Reverse cholesterol transport (RCT) is a physiological process that reduces excess cholesterol in the body. Cholesterol efflux (CE), an important step in RCT, is mainly mediated by ATP-binding cassette transporters A1 and G1 and has a significant role in atheroprotection. Moreover, impairments in CE can lead to the development of diabetes and fatty liver disease. In this review, we summarize the possible effects of hypoglycemic agents on CE and how this might influence atherosclerosis and dyslipidemia-related pathologies. Newer antidiabetic agents could have significant potential for targeting CE and preventing or alleviating atherosclerosis, obesity, and liver steatosis, and simultaneously improving insulin secretion. However, more research is warranted to interpret the clinical relevance of these data.

Address: School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9177948567, Iran.; Laboratory of Cellular and Molecular Pathology of Cardiovascular System, A.P. Avtsyn Research Institute of Human Morphology, 3 Tsyurupy Street, 117418 Moscow, Russian Federation.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Medicine, The University of Western Australia, Perth, WA, Australia; Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected].

DOI: 10.1016/j.drudis.2022.02.006

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MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 1, ATP-Binding Cassette Transporters, Atherosclerosis, Biological Transport, Cholesterol, Humans, Hypoglycemic Agents