Alcohol Dehydrogenases with anti-Prelog Stereopreference in Synthesis of Enantiopure Alcohols.

Musa M Musa

Journal: ChemistryOpen 2022;11(4):e202100251

PMID: 35191611

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Abstract

Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding prochiral ketones. This review covers examples of the synthesis of optically active alcohols using ADHs that exhibit anti-Prelog stereopreference. Both wild-type and engineered ADHs that exhibit anti-Prelog stereopreference are highlighted.

Address: Department of Chemistry Interdisciplinary Research Center for Refining and Advanced Chemicals, King Fahd University of Petroleum and Minerals, Dhahran, 31261, Saudi Arabia.

DOI: 10.1002/open.202100251

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MeSH Terms: Alcohol Dehydrogenase, Alcohols, Biocatalysis, Ketones, Stereoisomerism