Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium.

Raghubendra Singh Dagur, Rolf Teschke, Mihai Opris, Karuna Rasineni, Paul G Thomes, Larisa Poluektova, Moses New-Aaron, Arumugam Madan Kumar, Chava Srinivas, Murali Ganesan, Manuela G Neuman, Ramyajit Mitra, Raghabendra Adhikari, Steve D H Malnick, Lawrence B Cohen, Kusum K Kharbanda, Carol A Casey, Natalia A Osna, Pamela L Tuma, Helmut K Seitz

Journal: Experimental and molecular pathology 2022;126():104750

PMID: 35192844

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Abstract

The present review is based on the research presented at the symposium dedicated to the legacy of the two scientists that made important discoveries in the field of alcohol-induced liver damage: Professors C.S. Lieber and S.W. French. The invited speakers described pharmacological, toxicological and patho-physiological effects of alcohol misuse. Moreover, genetic biomarkers determining adverse drug reactions due to interactions between therapeutics used for chronic or infectious diseases and alcohol exposure were discussed. The researchers presented their work in areas of alcohol-induced impairment in lipid protein trafficking and endocytosis, as well as the role of lipids in the development of fatty liver. The researchers showed that alcohol leads to covalent modifications that promote hepatic dysfunction and injury. We concluded that using new advanced techniques and research ideas leads to important discoveries in science.

Address: In Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada. Electronic address: [email protected].; Centre of Liver and Alcohol Diseases, Ethianum Clinic, University of Heidelberg, Germany.; The Catholic University of America, Department of Biology, Washington, DC 20064, USA.; VA-Nebraska-Western Iowa Health Care System, Department of Veterans' Affairs, Omaha, NE, and Department of Internal Medicine, Section of Gastroenterology-Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.; Division of Gastroenterology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.; Department of Internal Medicine C, Kaplan Medical Center, Affiliated Hebrew University, Jerusalem, Israel.; In Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada; Family Medicine Clinic CAR, Bucharest, Romania.; Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Hanau, Academic Teaching Hospital of the Medical Faculty, Goethe University Frankfurt/ Main, Frankfurt/Main, Germany.

DOI: 10.1016/j.yexmp.2022.104750

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MeSH Terms: Ethanol, Humans, Liver, Liver Diseases, Alcoholic, Translational Research, Biomedical