Application of extracellular vesicles derived from mesenchymal stem cells as potential therapeutic tools in autoimmune and rheumatic diseases.

Huldani Huldani, Saade Abdalkareem Jasim, Dmitry Olegovich Bokov, Walid Kamal Abdelbasset, Mohammed Nader Shalaby, Lakshmi Thangavelu, Ria Margiana, Maytham T Qasim

Journal: International immunopharmacology 2022;106():108634

PMID: 35193053

Full Text on Elsevier Science View on PubMed

Abstract

Mesenchymal stem cells (MSCs) have been proven to have superior potential to be used astherapeutic candidates in various disorders. Nevertheless, the clinical application of these cells have been restricted because of their tumorigenic properties. Increasing evidence has established that the valuable impacts of MSCs are mainly attributable to the paracrine factors including extracellular vesicles (EVs). EVs are nanosized double-layer phospholipid membrane vesicles contain various proteins, lipids and miRNAs which mediate cell-to-cell communications. Due to their inferior immunogenicity and tumorigenicity, as well as easier management, EVs have drawn attention as potential cell-free replacement therapy to MSCs. For that reason, herein, we reviewed the recent findings of researches on different MSC-EVs and their effectiveness in the treatment of several autoimmune and rheumatic diseases including multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis, osteoarthritis, osteoporosis, and systemic lupus erythematosus as well as Sjogren's syndrome, systemic sclerosis and other autoimmune diseases.

Address: Department of Physiology, Lambung Mangkurat University, Banjarmasin, South Borneo, Indonesia. Electronic address: [email protected].; Medical Laboratory Techniques Department, Al-maarif University College, Al-anbar-Ramadi, Iraq.; Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow 119991, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow 109240, Russian Federation.; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.; Biological Sciences and Sports Health Department, Faculty of Physical Education, Suez Canal University, Egypt.; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, India.; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.; Department of Anesthesia, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq.

DOI: 10.1016/j.intimp.2022.108634

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MeSH Terms: Autoimmune Diseases, Extracellular Vesicles, Humans, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Rheumatic Diseases