Intestinal bile acids can bind to and activate the vitamin D receptor.

George Wolf

Journal: Nutrition reviews 2002;60(9):281-3

PMID: 12296454

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Abstract

An increased level of colon lithocholic acid, a potential tumor promoter, accompanies a high-fat diet. Lithocholic acid can bind to the intestinal vitamin D receptor and thereby induce the cytochrome CYP3A, which detoxifies lithocholic acid by catabolic reactions.

Address: Department of Nutritional Sciences and Toxicology, University of California, Berkeley 94720-3104, USA.

DOI: 10.1301/002966402320387206

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MeSH Terms: Bile Acids and Salts, Humans, Intestines, Lithocholic Acid, Receptors, Calcitriol