Screening, diagnosis and monitoring of sarcopenia: When to use which tool?

Leanne L G C Ackermans, Joyce Rabou, M Basrai, A Schweinlin, S C Bischoff, O Cussenot, G Cancel-Tassin, R J Renken, E Gómez, P Sánchez-González, A Rainoldi, G Boccia, K W Reisinger, Jan A Ten Bosch, Taco J Blokhuis

Journal: Clinical nutrition ESPEN 2022;48():36-44

PMID: 35331514

Free Full Text on University of Turin Instituional Repository AperTO - Free full text View on PubMed

Abstract

BACKGROUND & AIMS

Sarcopenia is a muscle disorder associated with loss of muscle mass, strength and function. Early screening, diagnosis and treatment may improve outcome in different disease conditions. A wide variety of tools for estimation of muscle mass is available and each tool has specific technical requirements. However, different investigational settings and lack of homogeneity of populations influence the definition of gold standards, proving it difficult to systematically adopt these tools. Recently, the European Working Group on Sarcopenia in Older People (EWGSOP) published a revised recommendation (EWGSOP-2) and algorithm for using tools for screening and diagnosing sarcopenia. However, agreement of the EWGSOP2 criteria with other classifications is poor and although an overview of available tools is valuable, for the purpose of clinical decision-making the reverse is useful; a given scenario asks for the most suitable tools.

RESULTS

Tools were identified for screening, diagnostics and longitudinal monitoring of muscle mass. For each of these clinical scenarios the most appropriate tools were listed and for each technique their usability is specified based on sensitivity and specificity. Based on this information a specific recommendation is made for each clinical scenario.

CONCLUSION

This narrative review provides an overview of currently available tools and future developments for different clinical scenarios such as screening, diagnosis and longitudinal monitoring of alterations in muscle status. It supports clinical decision-making in choosing the right tools for muscle mass quantification depending on the need within a given clinical scenario as well as the local availability and expertise.

Address: Department of Traumatology, Maastricht University Medical Centre+, 6229HX, Maastricht, the Netherlands; Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6229 HX, Maastricht, the Netherlands. Electronic address: [email protected].; Department of Traumatology, Maastricht University Medical Centre+, 6229HX, Maastricht, the Netherlands. Electronic address: [email protected].; Institute of Nutritional Medicine (180a), University of Hohenheim, 70593, Stuttgart, Germany. Electronic address: [email protected].; Institute of Nutritional Medicine (180a), University of Hohenheim, 70593, Stuttgart, Germany. Electronic address: [email protected].; Institute of Nutritional Medicine (180a), University of Hohenheim, 70593, Stuttgart, Germany. Electronic address: [email protected].; GRC n°5 Predictive Onco-Urology, Sorbonne Université, AP-HP, Hopital Tenon, Paris, 75013, France. Electronic address: [email protected].; GRC n°5 Predictive Onco-Urology, Sorbonne Université, AP-HP, Hopital Tenon, Paris, 75013, France. Electronic address: [email protected].; Neuroimaging Center, Cognitive Neuroscience Center, Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, Groningen, the Netherlands. Electronic address: [email protected].; Biomedical Engineering and Telemedicine Centre, ETSI Telecomunicación, Center for Biomedical Technology, Universidad Politécnica de Madrid, Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28040, Madrid, Spain. Electronic address: [email protected].; Biomedical Engineering and Telemedicine Centre, ETSI Telecomunicación, Center for Biomedical Technology, Universidad Politécnica de Madrid, Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28040, Madrid, Spain. Electronic address: [email protected].; Neuromuscular Function | Research Group, School of Exercise and Sport Sciences (SUISM), Department of Medical Sciences, University of Turin, Turin, Italy. Electronic address: [email protected].; NeuromuscularFunction | Research Group, School of Exercise and Sport Sciences (SUISM) and Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. Electronic address: [email protected].; Department of Traumatology, Maastricht University Medical Centre+, 6229HX, Maastricht, the Netherlands.; Department of Traumatology, Maastricht University Medical Centre+, 6229HX, Maastricht, the Netherlands. Electronic address: [email protected].; Department of Traumatology, Maastricht University Medical Centre+, 6229HX, Maastricht, the Netherlands. Electronic address: [email protected].

DOI: 10.1016/j.clnesp.2022.01.027

Link outs

Free resources

Full Text Sources:

Subscription / membership required

Full Text Sources:

https://www.clinicalkey.com/content/playBy/pii?v=S...

MeSH Terms: Aged, Humans, Sarcopenia