Nutraceuticals: unlocking newer paradigms in the mitigation of inflammatory lung diseases.

Yinghan Chan, Venkata Sita Rama Raju Allam, Keshav Raj Paudel, Sachin K Singh, Monica Gulati, Muralikrishnan Dhanasekaran, Piyush Kumar Gupta, Niraj Kumar Jha, Hari Prasad Devkota, Gaurav Gupta, Philip M Hansbro, Brian Gregory George Oliver, Dinesh Kumar Chellappan, Kamal Dua

Journal: Critical reviews in food science and nutrition 2023;63(19):3302-3332

PMID: 34613853

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Abstract

Persistent respiratory tract inflammation contributes to the pathogenesis of various chronic respiratory diseases, such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. These inflammatory respiratory diseases have been a major public health concern as they are the leading causes of worldwide mortality and morbidity, resulting in heavy burden on socioeconomic growth throughout these years. Although various therapeutic agents are currently available, the clinical applications of these agents are found to be futile due to their adverse effects, and most patients remained poorly controlled with a low quality of life. These drawbacks have necessitated the development of novel, alternative therapeutic agents that can effectively improve therapeutic outcomes. Recently, nutraceuticals such as probiotics, vitamins, and phytochemicals have gained increasing attention due to their nutritional properties and therapeutic potential in modulating the pathological mechanisms underlying inflammatory respiratory diseases, which could ultimately result in improved disease control and overall health outcomes. As such, nutraceuticals have been held in high regard as the possible alternatives to address the limitations of conventional therapeutics, where intensive research are being performed to identify novel nutraceuticals that can positively impact various inflammatory respiratory diseases. This review provides an insight into the utilization of nutraceuticals with respect to their molecular mechanisms targeting multiple signaling pathways involved in the pathogenesis of inflammatory respiratory diseases.

Address: School of Pharmacy, International Medical University (IMU), Kuala Lumpur, Malaysia.; Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.; Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia.; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.; Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, Alabama, USA.; Department of Life Sciences, School of Basic Sciences and Research (SBSR), Sharda University, Greater Noida, Uttar Pradesh, India.; Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, Uttar Pradesh, India.; Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto, Japan.; School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, India.; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.; Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia.; Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.; Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, Uttar Pradesh, India.; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, Australia.; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, Australia.

DOI: 10.1080/10408398.2021.1986467

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MeSH Terms: Humans, Quality of Life, Dietary Supplements, Asthma, Respiratory Tract Diseases