Metabolomics in Parkinson's disease.

Jacopo Troisi, Annamaria Landolfi, Pierpaolo Cavallo, Francesca Marciano, Paolo Barone, Marianna Amboni

Journal: Advances in clinical chemistry 2021;104():107-149

PMID: 34462054

Full Text on Elsevier Science View on PubMed

Abstract

Parkinson's disease (PD) is a multifactorial neurodegenerative disorder in which environmental (lifestyle, dietary, infectious disease) factors as well as genetic make-up play a role. Metabolomics, an evolving research field combining biomarker discovery and pathogenetics, is particularly useful in studying complex pathophysiology in general and Parkinson's disease (PD) specifically. PD, the second most frequent neurodegenerative disorder, is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of intraneural inclusions of α-synuclein aggregates. Although considered a predominantly movement disorder, PD is also associated with number of non-motor features. Metabolomics has provided useful information regarding this neurodegenerative process with the aim of identifying a disease-specific fingerprint. Unfortunately, many disease variables such as clinical presentation, motor system involvement, disease stage and duration substantially affect biomarker relevance. As such, metabolomics provides a unique approach to studying this multifactorial neurodegenerative disorder.

Address: Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, SA, Italy; Theoreo Srl, Montecorvino Pugliano, SA, Italy; European Biomedical Research Institute of Salerno (EBRIS), Salerno, SA, Italy. Electronic address: [email protected].; Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, SA, Italy.; Department of Physics, University of Salerno, Fisciano, SA, Italy; Istituto Sistemi Complessi del Consiglio Nazionale delle Ricerche (ISC-CNR), Roma, RM, Italy.; European Biomedical Research Institute of Salerno (EBRIS), Salerno, SA, Italy.

DOI: 10.1016/bs.acc.2020.09.003

Link outs

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Medical:

https://medlineplus.gov/parkinsonsdisease.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0065...

MeSH Terms: Humans, Metabolomics, Parkinson Disease