Iron acquisition by Gram-positive bacterial pathogens.

Jeremy S Brown, David W Holden

Journal: Microbes and infection 2002;4(11):1149-56

PMID: 12361915

Free Full Text on Elsevier Science View on PubMed

Abstract

For the majority of bacterial pathogens, acquisition of iron from host proteins is a prerequisite for growth during infection. The mechanisms by which Gram-negative bacteria obtain iron from host proteins have been well described, but only recently has substantial progress been made in identifying these mechanisms for Gram-positive bacterial pathogens. This review provides an overview of the existing knowledge on the genetic basis of iron transport for important Gram-positive pathogens.

Address: Department of Infectious Diseases, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Flowers Building, Armstrong Road, SW7 2AZ, London, UK. [email protected]

DOI: 10.1016/s1286-4579(02)01640-4

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MeSH Terms: Biological Transport, Corynebacterium diphtheriae, Gene Expression Regulation, Bacterial, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Humans, Iron, Listeria monocytogenes, Staphylococcus, Streptococcus pneumoniae, Streptococcus pyogenes