Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis.
Hanieh Shokrani, Amirhossein Shokrani, S Mohammad Sajadi, Farzad Seidi, Amin Hamed Mashhadzadeh, Navid Rabiee, Mohammad Reza Saeb, Tejraj Aminabhavi, Thomas J Webster
Journal: International journal of nanomedicine
2022;17():1035-1068
PMID: 35309965
Abstract
["One of the most arduous challenges in tissue engineering is neovascularization, without which there is a lack of nutrients delivered to a target tissue. Angiogenesis should be completed at an optimal density and within an appropriate period of\u00a0time to prevent cell necrosis. Failure to meet this challenge brings about poor functionality for the tissue in comparison with the native tissue, extensively reducing cell viability. Prior studies devoted to angiogenesis have provided researchers with some biomaterial scaffolds and cell choices for angiogenesis. For example, while most current angiogenesis approaches require a variety of stimulatory factors ranging from biomechanical to biomolecular to cellular, some other promising stimulatory factors have been underdeveloped (such as electrical, topographical, and magnetic). When it comes to choosing biomaterial scaffolds in tissue engineering for angiogenesis, key traits rush to mind including biocompatibility, appropriate physical and mechanical properties (adhesion strength, shear stress, and malleability), as well as identifying the appropriate biomaterial in terms of stability and degradation profile, all of which may leave essential trace materials behind adversely influencing angiogenesis. Nevertheless, the selection of the best biomaterial and cells still remains an area of hot dispute as such previous studies have not sufficiently classified, integrated, or compared approaches. To address the aforementioned need, this review article summarizes a variety of natural and synthetic scaffolds including hydrogels that support angiogenesis. Furthermore, we review a variety of cell sources utilized for cell seeding and influential factors used for angiogenesis with a concentrated focus on biomechanical factors, with unique stimulatory factors. Lastly, we provide a bottom-to-up overview of angiogenic biomaterials and cell selection, highlighting parameters that need to be addressed in future studies.",{"copyright":"\u00a9 2022 Shokrani et al."}]
Address:
Department of Chemical Engineering, Sharif University of Technology, Tehran, Iran.; Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.; Department of Nutrition, Cihan University-Erbil, Erbil, 625, Iraq.; Department of Phytochemistry, SRC, Soran University, Soran, KRG, 624, Iraq.; Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing, 210037, People's Republic of China.; Mechanical and Aerospace Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan.; Department of Physics, Sharif University of Technology, Tehran, Iran.; School of Engineering, Macquarie University, Sydney, New South Wales, 2109, Australia.; Department of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland.; School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, 580 031, India.; Department of Chemistry, Karnatak University, Dharwad, 580 003, India.; School of Health Sciences and Biomedical Engineering, Hebei University, Tianjin, People's Republic of China.; Center for Biomaterials, Vellore Institute of Technology, Vellore, India.
