Contribution of Interleukin-17A to Retinal Degenerative Diseases.

Huimin Zhong, Xiaodong Sun

Journal: Frontiers in immunology 2022;13():847937

PMID: 35392087

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Abstract

Retinal degenerative diseases are a leading cause of vision loss and blindness throughout the world, characterized by chronic and progressive loss of neurons and/or myelin. One of the common features of retinal degenerative diseases and central neurodegenerative diseases is chronic neuroinflammation. Interleukin-17A (IL-17A) is the cytokine most closely related to disease in its family. Accumulating evidence suggests that IL-17A plays a key role in human retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and glaucoma. This review aims to provide an overview of the role of IL-17A participating in the pathogenesis of retinal degenerative diseases, which may open new avenues for potential therapeutic interventions.

Address: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China.; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.

DOI: 10.3389/fimmu.2022.847937

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MeSH Terms: Diabetic Retinopathy, Humans, Interleukin-17, Macular Degeneration, Retina, Retinal Degeneration