Chemotherapeutic Activities of Dietary Phytoestrogens against Prostate Cancer: From Observational to Clinical Studies.

Suraiya Aktar, Zahed Bin Rahim, Md Sohel, Habiba Sultana, Tayeba Sultana, Abdullah Al Mamun, Mohammad Nurul Amin, Md Arju Hossain, Md Chayan Ali, Armin Sultana, Sarmistha Mitra, Raju Dash

Journal: Current pharmaceutical design 2022;28(19):1561-1580

PMID: 35652403

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Abstract

Prostate cancer remains one of the most frequent and deadliest malignancies in males, where the rate of disease progression is closely associated with the type of dietary intake, specifically a Western-style diet. Indeed intake of the Asian diet, which contains abundant phytoestrogens, is inversely correlated with a higher risk of prostate cancer, suggesting a chemoprotective effect of phytoestrogen against cancer progression. Although the role of phytoestrogens in cancer treatment has been well documented, their impact on prostate cancer is not well understood. Therefore, the present review discusses the possible chemopreventive effect of phytoestrogens, emphasizing their efficacy at the different stages of carcinogenesis. Furthermore, phytoestrogens provide a cytoprotective effect in conventional chemotherapy and enhance chemosensitivity to tumor cells, which have also been discussed. This compilation provides a solid basis for future research on phytoestrogens as a promising avenue for anticancer drug development and also recommends these beneficiary compounds in the daily diet to manage and prevent prostate cancer.

Address: Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail- 1902, Bangladesh.; Pratyasha Health Biomedical Research Center, Dhaka-1230. Bangladesh.; Department of Biotechnology and Genetic Engineering, Faculty of life science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.; Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka-1230, Bangladesh.; Pratyasha Health Biomedical Research Center, Dhaka-1230, Bangladesh.; Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh.; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.; Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Korea.

DOI: 10.2174/1381612828666220601153426

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MeSH Terms: Anticarcinogenic Agents, Diet, Humans, Male, Phytoestrogens, Prostatic Neoplasms