Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives.

Rajib Das, Daniela Calina, Yasaman Taheri, Saikat Mitra, Mohammed M Alshehri, Sevgi Durna Daştan, William C Cho, Javad Sharifi-Rad, Talha Bin Emran, Manoj Kumar, Prabhakar Semwal, Sakshi Painuli, Tareq Abu-Izneid, Abdur Rauf, Anshu Sharma

Journal: Oxidative medicine and cellular longevity 2022;2022():1035441

PMID: 35677108

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Abstract

Plants including , , and contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry. This review aims to provide an overview of the in vitro, in vivo, and clinical studies reporting the diosgenin's pharmacological effects and to discuss the safety issues. Preclinical studies have shown promising effects on cancer, neuroprotection, atherosclerosis, asthma, bone health, and other pathologies. Clinical investigations have demonstrated diosgenin's nontoxic nature and promising benefits on cognitive function and menopause. However, further well-designed clinical trials are needed to address the other effects seen in preclinical studies, as well as a better knowledge of the diosgenin's safety profile.

Address: Department of Biotechnology, Graphic Era University, Dehradun, 248002 Uttarakhand, India.; Pharmaceutical Sciences Department, College of Pharmacy, Al Ain University, Al Ain 64141, UAE.; Department of Chemistry, University of Swabi, Swabi, Anbar-23561, K.P .K, Pakistan.; Department of Food Science and Technology, Dr. Y.S. Parmar University of Horticulture and Forestry, Nauni, 173230, India.; Department of Biology, Faculty of Science, Sivas Cumhuriyet University, 58140 Sivas, Turkey.; Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, 58140 Sivas, Turkey.; Chemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai 400019, India.; Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.; Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

DOI: 10.1155/2022/1035441

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https://medlineplus.gov/asthma.html

MeSH Terms: Asthma, Diosgenin, Humans, Neoplasms, Phytochemicals, Plant Extracts, Trigonella