Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis.

Chunlu Yan, Jinlong Zhang, Fangyu An, Jiayu Wang, Yao Shi, Lingqing Yuan, Donghui Lv, Yanzhen Zhao, Yongfeng Wang

Journal: Frontiers in public health 2022;10():910675

PMID: 35844870

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Abstract

Ferroptosis was induced the programmed cell death with iron overload Fenton reaction. Currently, ferroptosis has not been studied thoroughly. Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. Other evidence supports that ferroptosis is participated osteoporotic bone remodeling, predominantly affecting the interaction between bone formation and bone resorption, explicitly bone resorption exceeded bone formation. Based on previous studies, this review will summarize the regulatory network mechanism of ferroptosis on bone remodeling and reveal the role of ferroptosis in osteoporosis (OP).

Address: School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, China.; The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, China.; Teaching Experiment Training Center, Gansu University of Chinese Medicine, Lanzhou, China.; School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, China.

DOI: 10.3389/fpubh.2022.910675

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Full Text Sources:

Medical:

https://medlineplus.gov/osteoporosis.html

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-3592

MeSH Terms: Bone Remodeling, Bone Resorption, Ferroptosis, Humans, Osteoporosis