Coexistence of Primary Sjögren's Syndrome and Autoimmune Gastritis With Pernicious Anemia and Subacute Combined Degeneration of the Spinal Cord: Case Report and Literature Review.

Hao-Su Zhan, Xin Yao, Hai-Yi Hu, Yan-Fei Han, Bing Yue, Li-Ying Sun, Yong-Jun Wang

Journal: Frontiers in immunology 2022;13():908528

PMID: 35812371

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Abstract

BACKGROUND

Autoimmune gastritis (AIG) and Primary Sjögren's syndrome (pSS) are both autoimmune diseases with low prevalence in China. Subacute combined degeneration (SCD) of the spinal cord is the most common neurological manifestation of vitamin B12 deficiency. Until now, a patient with pSS and complications of AIG including SCD has not been reported.

CASE PRESENTATION

A 69-year-old woman presented with palpitations and symmetrical and progressive numbness in her hands and feet. The patient had a sense of stepping on cotton and could not write or walk without help. We reviewed the patient's history and analyzed her blood tests, imaging, gastroscopic findings, and pathological results. The patient fulfilled the criteria of AIG, pSS, spinal cord SCD and early pernicious anemia (PA) simultaneously. Although pSS can lead to reduction of vitamin B12, this is the first overlapping case of pSS with spinal cord SCD. After symptomatic treatment, the patient returned to a normal life.

CONCLUSIONS

This first report about the coexistence of pSS and complications of AIG including SCD and PA will promote a better understanding of the relationship between these diseases.

Address: Department of Gastroenterology, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Department of Critical Liver Diseases, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Clinical Diagnosis, Treatment and Research Center of Pediatric Liver Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Clinical Center for Pediatric Liver Transplantation, Capital Medical University, Beijing, China.; Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

DOI: 10.3389/fimmu.2022.908528

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MeSH Terms: Aged, Anemia, Pernicious, Female, Gastritis, Humans, Sjogren's Syndrome, Subacute Combined Degeneration