Myelin water imaging in relapsing multiple sclerosis treated with ocrelizumab and interferon beta-1a.

Shannon Kolind, Shawna Abel, Carolyn Taylor, Roger Tam, Cornelia Laule, David K B Li, Hideki Garren, Laura Gaetano, Corrado Bernasconi, David Clayton, Irene Vavasour, Anthony Traboulsee

Journal: NeuroImage. Clinical 2022;35():103109

PMID: 35878575

Free Full Text on Elsevier Science View on PubMed

Abstract

[{"label":"BACKGROUND","text":"Myelin water imaging is a magnetic resonance imaging (MRI) technique \ufeffthat quantifies myelin damage and repair in multiple sclerosis (MS) via the myelin water fraction (MWF)."},{"label":"OBJECTIVE","text":"In this substudy of a phase 3 therapeutic trial, OPERA II, MWF was assessed in relapsing MS participants assigned to interferon beta-1a (IFNb-1a) or ocrelizumab (OCR) during a two-year double-blind period (DBP) followed by a two-year open label extension (OLE) with ocrelizumab treatment."},{"label":"METHODS","text":"MWF in normal appearing white matter (NAWM), including both whole brain NAWM and 5 white matter structures, and chronic lesions, was assessed in 29 OCR and 26 IFNb-1a treated participants at weeks 0, 24, 48 and 96 (DBP), and weeks 144 and 192 (OLE), and in white matter for 23 healthy control participants at weeks 0, 48 and 96."},{"label":"RESULTS","text":"Linear mixed-effects models of data from baseline to week 96 showed a difference in the change in MWF over time favouring ocrelizumab in all NAWM regions. At week 192, lesion MWF was lower for participants originally randomised to IFNb-1a compared to those originally randomised to OCR. Controls showed no change in MWF over 96\u00a0weeks in any region."},{"label":"CONCLUSION","text":"Ocrelizumab appears to protect against demyelination in MS NAWM and chronic lesions and may allow for a more permissive micro environment for remyelination to occur in focal and diffusely damaged tissue."},{"copyright":"Copyright \u00a9 2022 The Author(s). Published by Elsevier Inc. All rights reserved."}]

Address: Department of Medicine (Neurology), University of British Columbia, 2775 Laurel Street, Vancouver V5Z 1M9, Canada; Department of Radiology, University of British Columbia, 2775 Laurel Street, Vancouver V5Z 1M9, Canada; Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver V6T 1Z1, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, 818 West 10th Avenue, Vancouver, BC V5Z 1M9, Canada. Electronic address: [email protected].; Department of Medicine (Neurology), University of British Columbia, 2775 Laurel Street, Vancouver V5Z 1M9, Canada.; Applied Statistics and Data Science Group (ASDa), Department of Statistics, University of British Columbia, 3178-2207 Main Mall, Vancouver, V6T 1Z4, Canada.; Department of Radiology, University of British Columbia, 2775 Laurel Street, Vancouver V5Z 1M9, Canada; School of Biomedical Engineering, University of British Columbia, 251 - 2222 Heath Sciences Mall, Vancouver V6T 1Z3, Canada.; Department of Radiology, University of British Columbia, 2775 Laurel Street, Vancouver V5Z 1M9, Canada; Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver V6T 1Z1, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, 818 West 10th Avenue, Vancouver, BC V5Z 1M9, Canada; Department of Pathology & Laboratory Medicine, University of British Columbia, 2211 West Mall, Vancouver V6T 2B5, Canada.; Department of Radiology, University of British Columbia, 2775 Laurel Street, Vancouver V5Z 1M9, Canada.; Prothena Biosciences, 331 Oyster Point Boulevard, South San Francisco, CA 94080, USA.; F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel 4070, Switzerland.; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

DOI: 10.1016/j.nicl.2022.103109

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MeSH Terms: Antibodies, Monoclonal, Humanized, Brain, Double-Blind Method, Humans, Interferon beta-1a, Magnetic Resonance Imaging, Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Myelin Sheath, Recurrence, Water