The Essential Role of FoxO1 in the Regulation of Macrophage Function.

Shan Jie Rong, Chun Liang Yang, Fa Xi Wang, Fei Sun, Jia Hui Luo, Tian Tian Yue, Ping Yang, Qilin Yu, Shu Zhang, Cong-Yi Wang

Journal: BioMed research international 2022;2022():1068962

PMID: 35993049

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Abstract

Macrophages are widely distributed in various tissues and organs. They not only participate in the regulation of innate and adaptive immune response, but also play an important role in tissue homeostasis. Dysregulation of macrophage function is closely related to the initiation, development and prognosis of multiple diseases, including infection and tumorigenesis. Forkhead box transcription factor O1 (FoxO1) is an important member among the forkhead box transcription factor family. Through directly binding to the promoter regions of downstream target genes, FoxO1 is implicated in cell proliferation, apoptosis, metabolic activities and other biological processes. In this review, we summarized the regulatory role of FoxO1 in macrophage phagocytosis, migration, differentiation and inflammatory activation. We also emphasized that macrophage reciprocally modulated FoxO1 activity via a post-translational modification (PTM) dominant manner.

Address: The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.; Department of Clinical Nutrition, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.

DOI: 10.1155/2022/1068962

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https://assays.cancer.gov/CPTAC-1323

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-FOXO1-1

MeSH Terms: Apoptosis, Forkhead Box Protein O1, Forkhead Transcription Factors, Macrophages, Signal Transduction