The Molecular Mechanism of CoenzymeQ10 on Pyroptosis and its Related Diseases: A Review.

Qiong Xiang, Chuan-Jun Fu, Xian-Hui Li

Journal: Protein and peptide letters 2022;29(11):911-916

PMID: 36043779

Abstract

In recent years, cell pyroptosis has made it widely concerned. Pyroptosis is characterized by the activation of pathways leading to the activation of NLRP3 inflammasome and its downstream effector, such as interleukin (IL)-1β and IL-18, which has close relationship with inflammation. Recent evidence supports that CoenzymeQ10 (CoQ10) reduces related inflammatory factors (NLRP3, IL-1β and IL-18), which are associated with cell pyroptosis. This paper reviews the possible mechanisms of CoQ10 inhibiting pyroptosis of different cells and its possible mechanism. Further research is needed to better define the response effects of CoQ10 on specific aspects of cell pyroptosis (such as priming, promotion, and signaling), and to further investigate the organizational and cellular mechanisms by which CoQ10 reduces pyroptosis in different cells.

Address: Institute of Medicine, Medical Research Center, Jishou University, Hunan, China.; Institute of Pharmaceutical Sciences, Jishou University, Hunan, China.

DOI: 10.2174/0929866529666220829152631

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MeSH Terms: Humans, Pyroptosis, NLR Family, Pyrin Domain-Containing 3 Protein, Interleukin-18, Inflammasomes, Interleukin-1beta, Inflammation