Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles.

Javad Sharifi-Rad, Jesús Herrera-Bravo, Prabhakar Semwal, Sakshi Painuli, Himani Badoni, Shahira M Ezzat, Mai M Farid, Rana M Merghany, Nora M Aborehab, Mohamed A Salem, Surjit Sen, Krishnendu Acharya, Natallia Lapava, Miquel Martorell, Bekzat Tynybekov, Daniela Calina, William C Cho

Journal: Oxidative medicine and cellular longevity 2022;2022():5628601

PMID: 36105486

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Abstract

Artemisia plants are traditional and ethnopharmacologically used to treat several diseases and in addition in food, spices, and beverages. The genus is widely distributed in all continents except the Antarctica, and traditional medicine has been used as antimalarial, antioxidant, anticancer, antinociceptive, anti-inflammatory, and antiviral agents. This review is aimed at systematizing scientific data on the geographical distribution, chemical composition, and pharmacological and toxicological profiles of the Artemisia genus. Data from the literature on Artemisia plants were taken using electronic databases such as PubMed/MEDLINE, Scopus, and Web of Science. Selected papers for this updated study included data about phytochemicals, preclinical pharmacological experimental studies with molecular mechanisms included, clinical studies, and toxicological and safety data. In addition, ancient texts and books were consulted. The essential oils and phytochemicals of the Artemisia genus have reported important biological activities, among them the artemisinin, a sesquiterpene lactone, with antimalarial activity. Artemisia absinthium L. is one of the most famous Artemisia spp. due to its use in the production of the absinthe drink which is restricted in most countries because of neurotoxicity. The analyzed studies confirmed that Artemisia plants have many traditional and pharmacological applications. However, scientific data are limited to clinical and toxicological research. Therefore, further research is needed on these aspects to understand the full therapeutic potential and molecular pharmacological mechanisms of this medicinal species.

Address: Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.; Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile.; Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile.; Department of Life Sciences, Graphic Era Deemed To Be University, Dehradun, 248002, Uttarakhand, India.; Uttarakhand Council for Biotechnology (UCB), Prem Nagar, Dehradun, 248007 Uttarakhand, India.; Department of Biotechnology, School of Applied and Life Sciences, Uttaranchal University, Prem Nagar, Dehradun, 248007, Uttarakhand, India.; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza 12451, Egypt.; Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, P. O. 12622, Giza, Egypt.; Pharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), 33 El-Bohouth street, Dokki, Giza, Egypt.; Department of Biochemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza 12451, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Menoufia University, Gamal Abd El Nasr St., Shibin El Kom, 32511 Menoufia, Egypt.; Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata 700019, India.; Department of Botany, Fakir Chand College, Diamond Harbour, West Bengal 743331, India.; Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata 700019, India.; Medicine Standardization Department, Vitebsk State Medical University, Belarus.; Department of Nutrition and Dietetics, Faculty of Pharmacy, And Centre for Healthy Living, University of Concepción, Concepción, Chile.; Universidad de Concepción, Unidad de Desarrollo Tecnológico (UDT), 4070386 Concepción, Chile.; Department of Biodiversity of Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan.; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

DOI: 10.1155/2022/5628601

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MeSH Terms: Antimalarials, Artemisia, Medicine, Traditional, Oils, Volatile, Phytochemicals