Myokines: Novel therapeutic targets for diabetic nephropathy.

Shilu Luo, Jinfei Yang, Wei Chen, Liyu He, Di Liu, Ming Yang, Li Zhao, Xi Wang

Journal: Frontiers in endocrinology 2022;13():1014581

PMID: 36387916

Free Full Text on PubMed Central View on PubMed

Abstract

With the increasing incidence of diabetic nephropathy (DN), there is an urgent need to find effective DN preventive and therapeutic modalities. It is widely believed that effective exercise is good for health. However, the beneficial role of exercise in kidney disease, especially in DN, and the underlying molecular mechanisms have rarely been reported. Muscle is not only an important motor organ but also an important endocrine organ, secreting a group of proteins called "myokines" into the blood circulation. Circulating myokines then move to various target organs to play different biological roles. In this review, we summarize the currently known myokines and the progress in research relating them to DN and discuss its potential as a therapeutic target for DN.

Address: Department of Nutrition, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

DOI: 10.3389/fendo.2022.1014581

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/diabetickidneyproblems.htm...

MeSH Terms: Humans, Diabetic Nephropathies, Exercise, Diabetes Mellitus