Role of Advanced Glycation End Products in Intervertebral Disc Degeneration: Mechanism and Therapeutic Potential.

Fengguang Yang, Daxue Zhu, Zhaoheng Wang, Yingping Ma, Liangzeng Huang, Xuewen Kang, Bing Ma

Journal: Oxidative medicine and cellular longevity 2022;2022():7299005

PMID: 36573114

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Abstract

The incidence of low back pain caused by lumbar disc degeneration is high, and it can lead to loss of work ability and impose heavy social and economic burdens. The pathogenesis of low back pain is unclear, and there are no effective treatments. With age, the deposition of advanced glycation end products (AGEs) in intervertebral disc (IVD) gradually increases and is accelerated by diabetes and a high-AGEs diet, leading to destruction of the annulus fibrosus (AF), nucleus pulposus (NP), and cartilage endplate (CEP) and finally intervertebral disc degeneration (IDD). Reducing the accumulation of AGEs in IVD and blocking the transmission of downstream signals caused by AGEs have a significant effect on alleviating IDD. In this review, we summarize the mechanism by which AGEs induce IDD and potential treatment strategies.

Address: Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China.; The Second Clinical Medical College, Lanzhou University, Lanzhou, China.; Key Laboratory of Orthopedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China.; The International Cooperation Base of Gansu Province for the Pain Research in Spinal Disorders, Lanzhou, China.; Department of Orthopedics, Gansu Provincial Hospital, Lanzhou, Gansu 730000, China.

DOI: 10.1155/2022/7299005

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MeSH Terms: Humans, Intervertebral Disc Degeneration, Low Back Pain, Intervertebral Disc, Annulus Fibrosus, Glycation End Products, Advanced