Casein kinase 1: a Wnt'er of disconnect.

Paul Polakis

Journal: Current biology : CB 2003;12(14):R499-R501

PMID: 12176352

Free Full Text on Elsevier Science View on PubMed

Abstract

Phosphorylation of beta-catenin, a central downstream component of the Wnt pathway, by glycogen synthase kinase 3 is essential for its targeted degradation by the proteosome. New studies show that casein kinase 1 primes beta-catenin for subsequent phophorylation by glycogen synthase kinase 3.

Address: Department of Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. [email protected]

DOI: 10.1016/s0960-9822(02)00969-7

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MeSH Terms: Amino Acid Sequence, Casein Kinases, Cytoskeletal Proteins, Molecular Sequence Data, Phosphorylation, Protein Kinases, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Wnt Proteins, Zebrafish Proteins, beta Catenin