Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas.

Dipen J Parekh, Charlie Jung, Jeffery O'Conner, Sajal Dutta, Ernest R Smith

Journal: Urology 2002;60(1):164

PMID: 12100953

Full Text on Elsevier Science View on PubMed

Abstract

We report an unusual case of a leiomyosarcoma of the urinary bladder after chemotherapy for retinoblastoma and the results of a review of the published reports of bladder sarcomas. A 22-year-old man presented with hematuria and was found to have a mass in his urinary bladder on computed tomography. Transurethral resection of the mass revealed a leiomyosarcoma. The patient underwent radical cystectomy and an ileal conduit was created. The final pathologic examination confirmed high-grade leiomyosarcoma. Prospective randomized combination trials similar to the Intergroup Rhabdomyosarcoma Study in the pediatric population are necessary to better understand and manage these potentially curable sarcomas.

Address: Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2765, USA.

DOI: 10.1016/s0090-4295(02)01701-6

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MeSH Terms: Adult, Cyclophosphamide, Cystectomy, Hematuria, Humans, Leiomyosarcoma, Male, Prognosis, Retinal Neoplasms, Retinoblastoma, Urinary Bladder Neoplasms, Urinary Diversion