Does symbiotic supplementation which contains and fructooligosaccharide has favourite effects in patients with type-2 diabetes? A randomised, double-blind, placebo-controlled trial.

Mehdi Hedayati, Aynaz Velayati, Iman Kareem, Meghdad Sedaghat, Golbon Sohrab, Omid Nikpayam, Khadijeh Abhari, Ehsan Hejazi

Journal: Archives of physiology and biochemistry 2023;129(6):1211-1218

PMID: 34077686

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Abstract

This study aimed to determine the effect of symbiotic supplementation on metabolic factors and inflammation in patients with type-2 diabetes. In this clinical trial, 50 patients with type-2 diabetes were randomly assigned to the symbiotic (containing + + and fructooligosaccharide) or placebo groups to receive one sachet daily for 12 weeks. Glycaemic Index, lipid profile, and hs-CRP were measured at the beginning and end of the study. Analysis of covariance demonstrated that fasting blood glucose (FBG), insulin, homeostatic Model Assessment for Insulin Resistance (HOMA-IR), β-cell function (HOMA-β) ( <.05) and hs-CRP ( <.05) significantly declined in the treatment group compared with the placebo group. So, the current study indicated that symbiotic supplementation could improve metabolic factors and inflammation in patients with type-2 diabetes.

Address: Clinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences Tehran, Tehran, Iran.; Depatment of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Clinical Nutrition, faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.; Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Food Sciences and Technology Department, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

DOI: 10.1080/13813455.2021.1928225

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MeSH Terms: Humans, Lactobacillus acidophilus, Dietary Supplements, Lacticaseibacillus rhamnosus, Bacillus coagulans, C-Reactive Protein, Insulin, Insulin Resistance, Diabetes Mellitus, Type 2, Inflammation, Blood Glucose