The biosynthesis of adenosylcobalamin (vitamin B12).

Martin J Warren, Evelyne Raux, Heidi L Schubert, Jorge C Escalante-Semerena

Journal: Natural product reports 2002;19(4):390-412

PMID: 12195810

Full Text on Royal Society of Chemistry View on PubMed

Abstract

Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in Nature. Major progress has been made over the past decade in understanding how this synthesis is accomplished. This review covers some of the most important findings that have been made and provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl). 183 references are cited.

Address: School of Biological Sciences, Queen Mary, University of London, Mile End Road, London, UK E1 4NS. [email protected]

DOI: 10.1039/b108967f

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https://doi.org/10.1039/b108967f

MeSH Terms: Bacteria, Catalysis, Cobalt, Cobamides, Cyclization, Genes, Bacterial, Methyltransferases, Molecular Structure, Nucleotidyltransferases, Protein Conformation, Uroporphyrinogens, Uroporphyrins, Vitamin B 12