The impact of the gut microbiome on liver transplantation.

Nikki Duong, Jasmohan Singh Bajaj

Journal: Current opinion in organ transplantation 2021;26(6):587-594

PMID: 34636770

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Abstract

PURPOSE OF REVIEW

Although gut dysbiosis can hasten disease progression in end-stage liver disease and contribute to disease severity, morbidity and mortality, its impact during and after transplant needs further study.

RECENT FINDINGS

Changes in the microbiome are associated with hepatic decompensation. Immune homeostasis is further disrupted during transplant and with immunosuppressants required after transplant. There is increasing evidence of the role of microbiota in peri and posttransplant complications.

SUMMARY

Although transplant is highly successful with acceptable survival rates, infections, rejection, disease recurrence and death remain important complications. Prognostication and interventions involving the gut microbiome could be beneficial.

Address: Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, Virginia, USA.

DOI: 10.1097/MOT.0000000000000930

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MeSH Terms: Dysbiosis, End Stage Liver Disease, Gastrointestinal Microbiome, Humans, Liver Transplantation, Microbiota