Transferrin-mediated iron acquisition by pathogenic Neisseria.

R W Evans, J S Oakhill

Journal: Biochemical Society transactions 2003;30(4):705-7

PMID: 12196170

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Abstract

The pathogenic Neisseria have a siderophore-independent iron-uptake system reliant on a direct interaction between the bacterial cell and transferrin. In the meningococcus this uptake system is dependent on two surface-exposed transferrin-binding proteins. This short account will review our current knowledge of the transferrin-mediated iron-acquisition system of pathogenic Neisseria.

Address: Metalloprotein Research Group, The Randall Centre for Molecular Mechanisms of Cell Function, King's College London, 3.6A New Hunt's House, Guy's Campus, London SE1 1UL, UK. [email protected]

DOI: 10.1042/bst0300705

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MeSH Terms: Cell Membrane, Iron, Neisseria meningitidis, Receptors, Transferrin, Transferrin, Transferrin-Binding Proteins, Virulence