Malnutrition in Biliary Atresia: Assessment, Management, and Outcomes.

Julia M Boster, Amy G Feldman, Cara L Mack, Ronald J Sokol, Shikha S Sundaram

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2022;28(3):483-492

PMID: 34669243

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Abstract

Children with biliary atresia (BA), particularly infants, are at high risk for malnutrition attributed to a multitude of factors, including poor oral intake and intolerance of enteral feeding, fat malabsorption, abnormal nutrient metabolism, and increased caloric demand. Malnutrition and sarcopenia negatively impact outcomes in BA, leading to higher pretransplant and posttransplant morbidity and mortality. This review summarizes factors contributing to nutritional deficiencies in BA and offers an organized approach to the assessment and management of malnutrition in this vulnerable population.

Address: Department of Pediatrics, Pediatric Liver Center, Digestive Health Institute and Section of Pediatric Gastroenterology, Hepatology & Nutrition Children's Hospital ColoradoUniversity of Colorado School of Medicine Aurora CO USA.

DOI: 10.1002/lt.26339

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MeSH Terms: Biliary Atresia, Child, Enteral Nutrition, Humans, Infant, Liver Transplantation, Malnutrition, Nutritional Status, Sarcopenia