Dissecting the copper bioinorganic chemistry of the functional and pathological roles of the prion protein: Relevance in Alzheimer's disease and cancer.

Yanahi Posadas, Victor E López-Guerrero, José Segovia, Claudia Perez-Cruz, Liliana Quintanar

Journal: Current opinion in chemical biology 2022;66():102098

PMID: 34768088

Full Text on Elsevier Science View on PubMed

Abstract

The cellular prion protein (PrP) is a metal-binding biomolecule that can interact with different protein partners involved in pivotal physiological processes, such as neurogenesis and neuronal plasticity. Recent studies profile copper and PrP as important players in the pathological mechanisms of Alzheimer's disease and cancer. Although the copper-PrP interaction has been characterized extensively, the role of the metal ion in the physiological and pathological roles of PrP has been barely explored. In this article, we discuss how copper binding and proteolytic processing may impact the ability of PrP to recruit protein partners for its functional roles. The importance to dissect the role of copper-PrP interactions in health and disease is also underscored.

Address: Department of Chemistry, Center for Research and Advanced Studies (Cinvestav), Mexico City, 07350, Mexico; Department of Pharmacology, Center for Research and Advanced Studies (Cinvestav), Mexico City, 07350, Mexico.; Department of Chemistry, Center for Research and Advanced Studies (Cinvestav), Mexico City, 07350, Mexico; Department of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies (Cinvestav), Mexico City, 07350, Mexico.; Department of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies (Cinvestav), Mexico City, 07350, Mexico.; Department of Pharmacology, Center for Research and Advanced Studies (Cinvestav), Mexico City, 07350, Mexico.; Department of Chemistry, Center for Research and Advanced Studies (Cinvestav), Mexico City, 07350, Mexico. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2021.102098

Link outs

Free resources

Medical:

https://medlineplus.gov/alzheimersdisease.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-PRDX2-2

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1367...

MeSH Terms: Alzheimer Disease, Chemistry, Bioinorganic, Copper, Humans, Neoplasms, Prion Proteins