Sporadic Primary Hyperparathyroidism.

Stephanie J Kim, Dolores M Shoback

Journal: Endocrinology and metabolism clinics of North America 2022;50(4):609-628

PMID: 34774237

Full Text on Elsevier Science View on PubMed

Abstract

Sporadic primary hyperparathyroidism is a common endocrinopathy, particularly afflicting postmenopausal women and both African American men and women. Although classic signs and symptoms of the disease are well appreciated and described, because of the ease and availability and low threshold for screening, the disorder often is diagnosed in patients who are minimally symptomatic or asymptomatic. Surgery conducted by experienced endocrine surgeons has a high cure rate, particularly if guided by concordant imaging. In patients who cannot safely undergo surgery or who fail to be cured, medical therapy with the oral calcimimetic cinacalcet is a validated option for controlling serum calcium levels.

Address: Division of Endocrinology and Metabolism, University of California, 400 Parnassus Avenue A549, San Francisco, CA 94143, USA. Electronic address: [email protected].; Endocrine Research Unit - 111N, San Francisco Department of Veterans Affairs Medical Center, Division of Endocrinology and Metabolism, San Francisco VA Medical Center, University of California, 1700 Owens Street, 3rd floor Room 369, San Francisco, CA 94158, USA.

DOI: 10.1016/j.ecl.2021.07.006

Link outs

Subscription / membership required

Full Text Sources:

MeSH Terms: Calcium, Cinacalcet, Female, Humans, Hyperparathyroidism, Primary, Male