The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis.

Marinos Kosmopoulos, Martina Chiriacò, Kimon Stamatelopoulos, Costas Tsioufis, Pier Giorgio Masci, Christos Kontogiannis, Alessandro Mengozzi, Nicola Riccardo Pugliese, Stefano Taddei, Agostino Virdis, Stefano Masi, Georgios Georgiopoulos

Journal: Mechanisms of ageing and development 2022;201():111604

PMID: 34774607

Full Text on Elsevier Science View on PubMed

Abstract

Accelerated biological aging contributes to the evolution of cardiovascular disease. However, its influence on subclinical organ damage remains unclear. Leukocyte telomere length (LTL) is emerging as a marker of biological cardiovascular aging. We performed a systematic review and meta-analysis to assess the association between LTL and measures of end-organ damage. PubMed, Medline, Embase, Cinahl Plus, ClinicalTrials.gov, and grey literature databases were searched for studies that assessed the association of LTL with arterial pulse wave velocity (aPWV), carotid intima-media thickness (cIMT), left ventricular mass (LVM or LVMI), renal outcomes, coronary artery calcium (CAC) and presence of carotid plaques. In a sample of 7256 patients, we found that cIMT (pooled correlation coefficient (r) = -0.249; 95 %CI -0.37, -0.128) and aPWV (pooled r = -0.194; 95 % CI -0.290, -0.100) inversely correlate with LTL. Compared to aPWV, cIMT had a stronger correlation with LTL. Patients without carotid plaques had longer telomeres than patients with carotid plaques. Quantitative analyses documented LTL association with renal outcomes and CAC, but not with LVM/LVMI. Among measures of end-organ damage, cIMT and aPWV provide the most accurate information on the contribution of biological aging to the process of vascular remodeling/damage.

Address: Department of Medicine, Division of Cardiology, University of Minnesota, Minneapolis, USA.; Department of Clinical and Experimental Medicine, Università degli Studi di Pisa, Italy.; Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Greece.; First Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.; School of Biomedical Engineering and Imaging Sciences, King's College, London, UK.; Department of Clinical and Experimental Medicine, Università degli Studi di Pisa, Italy. Electronic address: [email protected].; Department of Clinical and Experimental Medicine, Università degli Studi di Pisa, Italy; Institute of Cardiovascular Science, University College London, London, UK.; Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Greece; School of Biomedical Engineering and Imaging Sciences, King's College, London, UK. Electronic address: [email protected].

DOI: 10.1016/j.mad.2021.111604

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MeSH Terms: Aging, Blood Vessels, Cardiovascular Physiological Phenomena, Cellular Senescence, Humans, Telomere Homeostasis, Vascular Remodeling