Stimuli-Responsive Natural Proteins and Their Applications.

Na Du, Fangfu Ye, Jing Sun, Kai Liu

Journal: Chembiochem : a European journal of chemical biology 2022;23(6):e202100416

PMID: 34773331

Abstract

Natural proteins are essential biomacromolecules that fulfill versatile functions in the living organism, such as their usage as cytoskeleton, nutriment transporter, homeostasis controller, catalyzer, or immune guarder. Due to the excellent mechanical properties and good biocompatibility/biodegradability, natural protein-based biomaterials are well equipped for prospective applications in various fields. Among these natural proteins, stimuli-responsive proteins can be reversibly and precisely manipulated on demand, rendering the protein-based biomaterials promising candidates for numerous applications, including disease detection, drug delivery, bio-sensing, and regenerative medicine. Therefore, we present some typical natural proteins with diverse physical stimuli-responsive properties, including temperature, light, force, electrical, and magnetic sensing in this review. The structure-function mechanism of these proteins is discussed in detail. Finally, we give a summary and perspective for the development of stimuli-responsive proteins.

Address: Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, P. R. China.; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.; Institute of Organic Chemistry, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany.; Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.

DOI: 10.1002/cbic.202100416

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https://doi.org/10.1002/cbic.202100416

MeSH Terms: Biocompatible Materials, Drug Delivery Systems, Temperature