Spin in the Scientific Literature on Bariatric Endoscopy: a Systematic Review of Randomized Controlled Trials.

Sayeh Shirvani, Claire Rives-Lange, Nathalie Rassy, Arthur Berger, Claire Carette, Tigran Poghosyan, Sébastien Czernichow

Journal: Obesity surgery 2022;32(2):503-511

PMID: 34783961

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Abstract

Bariatric endoscopy (BE) is an emerging treatment option for people with obesity. Spin (i.e., the practice of frequent misrepresentation or overinterpretation of study findings) may lead to imbalanced and unjustified optimism in the interpretation of the results. The aim of this systematic review was to determine the frequency and type of spin in randomized controlled trials (RCTs) of endoscopic primary weight loss techniques with statistically significant and nonsignificant primary outcomes. In conclusion, spin is observed in the abstract and main text of BE reports and can lead to misinterpretation or overinterpretation of the results. Since BE challenges the available non-endoscopic treatments for obesity, further research is needed to better qualify these techniques, as being effective and safe, as well as predefined hypotheses and analyses.

Address: UMR1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), METHODS team, INSERM, Paris, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, Service de Nutrition, Centre Spécialisé Obésité, Université de Paris, 20 rue Leblanc, 75015, Paris, France.; Département de Médecine Oncologique, Gustave Roussy, Villejuif, France.; Pôle hépato-gastro-entérologie, diabétologie, nutrition et endocrinologie, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.; INSERM, U1418, Centre d'Investigation Clinique (CIC), Université de Pairs, Paris, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Service de chirurgie digestive, Hôpital Européen Georges Pompidou, Université de Paris, Inserm UMRS 1149, Paris, France.; UMR1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), METHODS team, INSERM, Paris, France. [email protected].; Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, Service de Nutrition, Centre Spécialisé Obésité, Université de Paris, 20 rue Leblanc, 75015, Paris, France. [email protected].

DOI: 10.1007/s11695-021-05790-3

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https://dx.doi.org/10.1007/s11695-021-05790-3

MeSH Terms: Bariatrics, Endoscopy, Endoscopy, Gastrointestinal, Humans, Obesity, Obesity, Morbid, Randomized Controlled Trials as Topic